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Creatine Phosphate

Creatine phosphate is also called phosphocreatine or Pcr. It is a creatine molecule that is phosphorylated and is considered to be a primary energy source in skeletal muscles.

Adenosine tri phosphate can be anaerobically generated from adenosine di phosphate. In this process, there is an intense activity from 2 to 7 seconds during which a phosphate group is donated with creatine kinase acting as a catalyst. The resultant product is creatine and the reaction is reversible, which can be represented as

Creatine phosphate + ADP = Creatine + ATP

Since the energy obtained from a reaction is again used for regeneration of another compound, a coupling reaction occurs in which phosphocreatine is a part. This creatine phosphate helps in maintaining a constant adenosine tri phosphate level.

Creatine phosphate has a major role to play in tissues where the energy demands are highly fluctuating, for example, brain and muscle. Creatine phosphate flows through the bloodstream and reaches the muscle cells after being synthesized in liver. Later, this is stored in the muscle cells.

The IUPAC name of creatine phosphate is 2-[Methyl-(N-phosphonocarbamimidol)amino]acetic acid and has a molecular mass of 211.113 g/mol.
It is also sometimes referred to as creatine-P.

Energy Pathway of Creatine Phosphate:

When adenosine tri phosphate molecules of a muscle are liberated and the energy obtained as a resultant is utilized for the movement, there is a formation of ADP.

The ADP pool that is free in any muscle tissue will be available for the immediate requirement only for short period of time.

After this process, a phosphate group is transferred to adenosine di phosphate when the contractile activity takes place. This again leads to formation of adenosine tri phosphate which provides immense energy for any activity involving muscles.

The advantage of this process is when there is enough supplement of creatine phosphate in the diet; it helps in enhancing muscular contraction and thus enhances the performance. However, this is only for a short time.

Creatine Phosphate as an Energy source in Sports:

The intake of creatine can be made natural by including poultry, fish and meat in diet. Since creatine phosphate is a molecule with high energy, it is more likely to be a reservoir of energy. In natural state, our body has creatine phosphate which can be used only for 5-6 seconds of intense physical activity. Hence creatine phosphate covers all the temporary deficits of the adenosine tri phosphate molecule by acting as its energy buffer. This provides bundles of energy for a lot of physical activity that is involved in sports like sprinting and weight lifting.

Recent Research related to Creatine Phosphate:

When psoas fibers of glycerinated rabbit was tested, it is found that they are likely to contract because of the influence created by creatine phosphate and creatine kinase, when there is an absence of a free nucleotide.

Whereas, when creatine phosphate was added to a medium of creatine kinase, there was a development of tension observed.

Thus Creatine phosphate is mainly used in sports to enhance the physical activity over a long period of time.

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